Mount Sinai Hospital

Department of Paediatrics 5 year Report 2009-2013

Perspectives magazine is an annual glossy supporting the Mount Sinai Hospital Auxiliary, Mount Sinai Hospital and the Samuel Lunenfeld Research Institute.

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15 Research Research Since 2009, our department has rapidly developed its research capacity and is now easily the most productive research NICU in Canada. Department members are leading or involved in many studies including large Canada-wide and international multi-centre studies. These studies include the randomized controlled trial of our Family Integrated Care program led by Dr. Shoo Lee and Dr. Karel O'Brien, the EPIQ trial on NICU quality improvement led by Dr. Shoo Lee, the DOMINO and OptiMom studies on breast milk and neonatal nutrition led by Dr. Sharon Unger, and the iNeo outcomes study of nine countries led by Dr. Prakesh Shah. We would also like to congratulate Dr. Shoo Lee on his position as Scientific Director of the CIHR Institute of Human Development, Child and Youth Health; Dr. Prakesh Shah on receiving a CIHR Applied Chair in Reproductive and Child Health Research and his appointment as Director of the Canadian Neonatal Network (CNN) and the International Network for Evaluation of Outcomes in Neonates (iNeo); Dr. Ann Jefferies on being promoted to full Professor; Dr. Sharon Unger on her position as Medical Director of the Rogers Hixon Human Milk Bank and promotion to Associate Professor; and Dr Emer Finan on her position as Director of the University of Toronto Neonatal-Perinatal Fellowship Program. The number of clinician-scientists with protected research time increased from none in 2009 to 6 in 2013. In addition to physician researchers, our department also engages non-physician clinical staff in research, including nurses, dieticians, pharmacists, social workers, and respiratory therapists. In 2009, Dr. Shoo Lee established the Maternal-Infant Care Research Centre (MiCare), which includes 4 PhD scientists and 14 other research staff to support researchers in the department (see section on MiCare). In early 2014, researchers from the Department of Obstetrics and Gynaecology and Department of Obstetric Anesthesia at Mount Sinai will join MiCare to create a truly integrated perinatal and neonatal research centre. MiCare is affiliated with the Lunenfeld-Tanenbaum Research Institute, which will expand to include clinical research in late 2014. MiCare will then become the core of a new Clinical Research Centre for all clinical and research services at Mount Sinai. MiCare is funded through research grants from CIHR and the Ontario Ministry of Health and Long- Term Care. Research Areas Research in the department is clustered into 3 main groups: Developmental Biology and Physiology • Developmental and Stem Cell Biology of the Lung Dr. Sandra Leibel (PhD candidate) is a member of the developmental biology research group at the University of Toronto, and is developing a model to evaluate the mechanisms of inherited surfactant deficiency, which will potentially lead to the discovery of treatments that can be delivered in vivo to treat babies with surfactant deficiency. • Cardiac Physiology and Functional Echocardiography Dr. Amish Jain (PhD candidate) is a member of the developmental biology research group at the University of Toronto, and is studying cardiac physiology of the newborn infant and the use of functional echocardiography in diagnosis and management of cardiovascular problems. Patient-Oriented Research • Outcomes Research and Evidence-Based Medicine Dr. Prakesh Shah holds a CIHR Applied Chair in Reproductive and Child Health Research, and is Director of the CNN and iNeo. He maintains a population- based national database of all babies admitted to Canadian NICUs, as well as an international database of all very low birth weight babies admitted to NICUs in 9 countries (Canada, UK, Sweden, Spain, Switzerland, Israel, Japan, Australia, New Zealand), and conducts international comparative studies of neonatal outcomes. He is also a leader in evidence- based medicine and systematic reviews. • Quality Improvement and Health Services Research Dr. Shoo Lee is the Scientific Director of the Institute of Human Development, Child and Youth Health at the Canadian Institutes of Health Research, and Director of the CIHR Team in Maternal-Infant Care. He leads a national and international effort to improve quality of NICU care across 5 continents, and has demonstrated significant improvements in key neonatal outcomes both in Canada and internationally. He founded CNN, pioneered Family Integrated Care and is developing a

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