ASCO Connection

July 2017

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PP-ON-US-2032 04/17 ©Lilly USA, LLC 2017. All rights reserved. References: 1. Matsushime H, Ewen ME, Strom DK, et al. Identification and properties of an atypical catalytic subunit (p34 PSK-J3 /cdk4) for mammalian D type G1 cyclins. Cell. 1992;71:323-334. 2. Meyerson M, Harlow E. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol. 1994;14:2077-2086. 3. Coller HA. What's taking so long? S-phase entr y from quiescence versus proliferation. Nat Rev Mol Cell Biol. 2007;8:667-670. Lilly Oncology is committed to advancing the research for people living with breast cancer. FIND OUT AT ExploreCDK.com Do CDK4 & 6 play different roles? EXPLORATIONINSPIRATION IN BREAST CANCER Artist's rendition of the cyclin D—cyclin-dependent kinase 4 (CDK4) and cyclin-dependent kinase 6 (CDK6)—and retinoblastoma (Rb) protein pathways. 1-3

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