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Modernizing Life Science Manufacturing: How
analytics, IoT and the cloud are rewriting drug production
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Faced with an uptick in the discard rate of certain
vaccines, Merck gathered all the data generated at
one of its manufacturing sites into a data lake in
the cloud. Pooling minute-by-minute temperature
readings, batch process control records and other
site data into the data lake enabled Merck to analyze
the site holistically for the first time
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Once Merck visualized data from every batch produced
by the plant, it identified a correlation between yield
and fermentation performance traits that suggested
a root cause of its problem. The process took 15
billion calculations and 5.5 billion batch-to-batch
comparisons, a level of computing beyond the reach
of their on-premises IT systems. The on-demand
scalability and compute power of the AWS Cloud
allowed Merck to improve the manufacturing
production output for its drug product.
S i m i l a r l y, S a n F r a n c i s c o - b a s e d B i g f i n i t e i s
u s i n g t h e AWS C l o u d a n d m a c h i n e l e a r n i n g
4 AWS re:Invent 2014 | (HLS201) Using AWS and Data Science to Analyze
Vaccine Yield. (2014).
t o s t ore a n d a n a l y z e t h e d i s p a r at e s ou rc e s of
d at a g e n e r at e d by b i o p h a r m a m a nu f a c t u re r s .
Pre v iously, t hes e d at a s ources l argely s at si lo e d
in legacy applications, limiting companies' ability
to g l e an i ns i g ht s f rom t h e m .
Bigfinite built an analytics platform that pulls in
data from multiple manufacturing data sources like
connected production equipment, Manufacturing
Execution Systems (MES), Quality Management
Systems (QMS) and ERPs, and analyzes it using
machine learning, artificial intelligence and neural
networks. Using the AWS Cloud for these tasks
allows bigfinite to provide a GxP-compliance-ready
environment that can capture, store, interpret, analyze
and model disparate data sources at large scales to
help optimize manufacturing processes.
T h i s m a ch i ne l e ar n i ng - p owe re d appro a ch i s
delivering b enef its to manufacturers to day. A
multinational company used Bigfinite's platform
in one of its European plants, where 50 reactors
mix compounds in parallel and subsequently release
