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iv Contents Introduction 1 Definitions 1 General Design Principles 2 Scenarios 6 Loosely Coupled, High-Throughput Computing 8 Tightly Coupled, High-Performance Computing 16 The Pillars of the Well-Architected Framework 21 Operational Excellence Pillar 21 Security Pillar 24 Reliability Pillar 27 Performance Efficiency Pillar 31 Cost Optimization Pillar 38 Conclusion 42 Contributors 42 Further Reading 42