Life Sciences

HPC Lens for the AWS Well-Architected Framework

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Amazon Web Services – HPC Lens AWS Well-Architected Framework Page 4 simulations decreases their chance of safe evacuation. On-Demand Instances must be used for these simulations to allow for the bursting of analyses while ensuring that results are obtained without interruption. o Every morning weather forecasts are run for television broadcasts in the afternoon. Scheduled Reserved Instances can be used to make sure the needed capacity is available every day at the right time. Use of this pricing model also provides a discount compared with On- Demand Instances. • Start from the data: Before you start designing the architecture, you should have a clear picture of where the data comes from, how large it is, how fast it needs to travel, how frequently data sources are updated, and where the data needs to be stored. Similarly, a holistic optimization of performance and cost shouldn't focus exclusively on compute cores and Amazon Elastic Compute Cloud (Amazon EC2) performance. AWS has a strong offering of data services that are not part of the traditional HPC landscape, but they can enable you to extract the most value from your data. • Automate to simplify architectural experimentation: Automation through code allows you to create and replicate your systems at low cost and avoid the expense of manual effort. You can track changes to your code, audit the impact, and revert to previous parameters when necessary. The ability to easily experiment with infrastructure allows you to optimize the architecture for performance and cost. • Enable collaboration: HPC work often occurs in a collaborative context, sometimes spanning many countries around the world. Beyond immediate collaboration, methods and results are often shared with the wider HPC and scientific community. It's important to consider in advance which tools, code, and data may be shared and with whom. The delivery methods should be part of this design process. For example, workflows can be shared in many ways on AWS: You can use Amazon Machine Images (AMIs), Amazon Elastic Block Store (Amazon EBS) snapshots, Amazon Simple Storage Service (Amazon S3) buckets, AWS CloudFormation templates, AWS Marketplace products, and scripts. Take full advantage of AWS security and collaboration features that make AWS an excellent environment for you and your collaborators to

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