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Modernizing clinical trials with digital technologies and the cloud

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Modernizing Clinical Trials: Digital Technologies and the Cloud 3 Published by FiercePharma compute environments to our PK scientists. Instead of being able to run hundreds, they can now run thousands of clinical trials to prepare these optimized design runs," Russell Towell, a Senior Solutions Specialist at Bristol-Myers Squibb, said. 5 By using these cloud- based trial simulations, they were able to reduce the number of subjec ts by one-third, and reduce the length of the study by almost a year. Utilization of highly scalable, on- demand cloud - based computation power for in silico clinical trial simulations can help in the upfront optimization of these trials, decreasing patient and trial site burden and potentially speeding time to completion. OPTIMIZING PATIENT AND TRIAL SITE SELECTION WITH ADVANCED ANALYTICS The average clinical development program takes 10 to 15 years to complete, in par t due to protocol 5 Bristol-Myers Squibb on AWS - Customer Success Stor y. (2013). ht tps://w w w.youtube.com/watch?v=Vi96Wr x ASgo complexity and patient recruitment and retention. 6 The current process of protocol design involves a labor-intensive process by which researchers use benchmark studies and historical data to predict the protocol feasibilit y based on its projec ted rate of recruitment, which are of ten immediately outdated given an ever-evolving competitive landscape. To aid in these ef for ts, companies are looking to ar tificial intelligence and machine learning (AI/ML) to help expedite and optimize patient recruitment. For example, Knowledgent has built an Intelligent Trial Planning (ITP) application on the AWS Cloud that uses AI/ML to predic t the feasibility of clinical trials and forecast recruitment timelines. The ITP platform enables study design teams at pharma organizations to run predic tion analysis in minutes, not weeks, 6 How long a new drug takes to go through clinical trials. Cancer Research UK (2014). Available at: ht tps://w w w. cancerresearchuk.org/about- cancer/find-a- clinical-trial/how- clinical-trials-are -planned-and- organised/how-long-it-takes- for-a-new- drug-to - go -through- clinical-trials. (Accessed: 11th December 2018)

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