3
1. Blauwkamp T., et al. Nat. Microbiol. 2019;4(4):663-674.
https://www.ncbi.nlm.nih.gov/pubmed/30742071
A GENOMEWEB / AWS WHITE PAPER
JANUARY 2020
Next, a relative abundance is calculated for each
microbial taxon detected in the sample. The third
VWHSLVWRƓOWHURXWDQ\SRWHQWLDOIDOVHSRVLWLYHV
VXFKDVLGHQWLƓFDWLRQRIPLFURELDOFHOOIUHH'1$
that originated from the environment.
ŏ7KH ZD\ WKH ƓOWHU ZRUNV LV E\ XVLQJ WKH VHW
of control samples that are processed and
sequenced within each batch," explained Dr.
Bercovici. "A probabilistic approach is trained
on these control samples, per batch, and that
DOORZVXVWRƓOWHUZKDWDSSHDUVWREHEDFNJURXQG
noise." A key point is that the contamination
SURƓOHFKDQJHVRYHUWLPHŏ