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AWS Digital Therapeutics Whitepaper

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7. Sanofi and Happify Health solidify collaboration around prescription DTx designed to address mental health in people with MS. https://www.sanofi.com/en/media- room/articles/2019/happify-collaboration. 8. Landi, H. Digital therapeutics company Proteus Digital Health files for Chapter 11 bankruptcy. https://www.fiercehealthcare.com/tech/digital-medicine-company- proteus-digital-health-files-for-chapter-11-bankruptcy (2020). 9. Amazon Web Services. The Case for Digital Therapeutics. https://www.youtube. com/watch?v=jqKlsRqpQi0 (2019). 10. Propeller Health | Outcomes. Propeller Health https://www.propellerhealth.com/ outcome/. 11. Chrystyn, H. et al. Real-life inhaler technique in asthma patients using the electronic ProAir Digihaler. Eur. Respir. J. 54, (2019). 12. etectRx Announces U.S. FDA Clearance of Novel Ingestible Event Marker | etectRx. https://etectrx.com/etectrx-announces-u-s-fda-clearance-of-novel-ingestible- event-marker/. 13. Chai, P. R. et al. Oxycodone Ingestion Patterns in Acute Fracture Pain With Digital Pills. Anesth. Analg. 125, 2105–2112 (2017). 14. Chai, P. R. et al. Short Communication: Bioequivalence of Tenofovir Component of Tenofovir/Rilpivirine/Emtricitabine in Digital Pills. AIDS Res. Hum. Retroviruses 35, 361–363 (2019). 15. AWS Events. AWS re:Invent 2019: Digital therapeutics and patient personalization (LFS202). https://www.youtube.com/watch?v=txtbBu-Skwo (2019). 16. Amazon Web Services. Propeller Health Leverages AWS to Help Patients Manage Respiratory Disease. https://www.youtube.com/watch?v=VYVphIBZ2mU (2020). 17. Barrett, M. et al. AIR Louisville: Addressing Asthma With Technology, Crowdsourcing, Cross-Sector Collaboration, And Policy. Health Aff. 37, 525–534 (2018). 18. ProAir® DigihalerTM (albuterol sulfate) with companion mobile app. https://www. proairdigihaler.com/. 19. Propeller Health sensor to be co-packaged with recently approved Enerzair® Breezhaler® asthma medication in Europe - Propeller Health. Propeller Health https://www.propellerhealth.com/press/press-release/propeller-health-sensor-to- be-co-packaged-with-recently-approved-enerzair-breezhaler-asthma-medication- in-europe/ (2020). 20. Cutanea Life Sciences, Inc. Cutanea Life Sciences Unveils 'Facing ForwardTM,' New Mobile Application for Acne Patients. PR Newswire https://www.prnewswire. com/news-releases/cutanea-life-sciences-unveils-facing-forward-new-mobile- application-for-acne-patients-300495959.html (2017). 21. Knowler, W. C. et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346, 393–403 (2002). 22. Dutra, L. et al. A meta-analytic review of psychosocial interventions for substance use disorders. Am. J. Psychiatry 165, 179–187 (2008). 23. Magill, M. & Ray, L. A. Cognitive-behavioral treatment with adult alcohol and illicit drug users: a meta-analysis of randomized controlled trials. J. Stud. Alcohol Drugs 70, 516–527 (2009). DIGITAL THERAPEUTICS: HOW CLOUD TECHNOLOGY IS ENHANCING PATIENT EXPERIENCE AND OUTCOMES 9 OCTOBER 2020 PRESENTED BY: PUBLISHED BY:

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