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AWS Genomics Executive Brief

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© 2021, Amazon Web Services, Inc. or its Affiliates. All rights reserved. Optimize cost While sequencing costs have fallen, costs associated with compute and storage have grown as organizations continues to increase throughput and explore more data - heavy applications, such as single - cell genomics. In contrast to on - premises setups that require large upfront investments and continuous CapEx , AWS enables genomics organization to use only what they need, when they need it. AWS offers storage and compute offerings at a variety of price points. Services such as Amazon EC2 Spot Instances offer up to 90 precent discounts in comparison to on - demand compute prices. For long - term storage of infrequently used data, Amazon S3 Glacier provides secure data archiving starting at $1 per terabyte per month. Genomics organizations also leverage AWS to reduce development and operational costs. By building its AI - based genomics intelligence platform on AWS, Emedgene reduced its costs of applying artificial intelligence to big genomics by 70 percent while accelerating model development and optimization. Reduce time to discovery Genomics is a data - heavy discipline requiring extensive compute resources to analyze samples and extract meaningful insights. To accelerate discoveries, AWS offers a robust suite of powerful compute and machine learning options that enable scientists to process more samples, run more complex analyses, and query at - scale. The only cloud provider to deliver 100 Gbps of networking throughput, AWS delivers high - throughput data ingestion, analysis, and interpretation services and tools designed to help genomics organizations get more from their data. Genomics organizations such as Fauna Bio leverage the robust computation power of AWS to analyze multi - omic datasets, accelerate research, and uncover new discoveries. Accelerate data analysis With native integration to workflow tools, including Nextflow and Cromwell, organizations can orchestra AWS Batch processes to accelerate processing time for computational analysis. For example, with AWS Fred Hutch was able to reduce compute time from seven years down to seven days, accelerating the organizations research on developing therapeutics to fight cancer. Simplify data interpretation The full value of genomic data is recognized once its put into context. Population genomics programs across the globe leverage the security, flexibility, and scalability of AWS to host population - scale biobanks and provide democratized access to the industry. Using querying and machine learning services from AWS, scientists can rapidly query datasets, including the Cancer Genome Atlas (TCGA) and the Broad Institute's Genome Aggregation Database (gnomAD) hosted on AWS registry of open data , to rapidly extract insights and answers. Munich Leukemia Lab Uses AWS FPGAs to Reduce Genome - Data Processing Time from 20 hours to > 3 hours Dedicate 20% more IT resources to software development 70% c ost reduction for AI implementation using AWS

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