Models of Type 2 Diabetes
2
Strain
C57BL/6J
Diet - Induced Obesity
BKS.Cg - Dock7
m +/+
Lepr
db
/J BTBR.V(B6) - Lep
ob
/ WiscJ
Stock#
380050 642 4824
Common Name
DIO db / db ob / ob
Obesity
with 60% high fat diet at 4 weeks at 6 weeks
Glucose Intolerance
by 8 weeks by 8 weeks early & severe
Hyperglycemia
Elevated to pre - diabetic levels
by 8 weeks.
prolonged by 8 weeks severe by 10 weeks
Insulin
Hyperinsulinemia
Transient hyperinsulinemic
(at 10 - 14 days)
Early hypersecretion of insulin,
then hypoinsulinemic
Polyphagic
No Yes Yes
Metabolism
Hypermetabolic Hypometabolic
Diabetes
Pre - diabetic M by 6 weeks; F by 8 weeks
Cons
Stress effects phenotype
Sever islet atrophy and death by
10 months.
Early glomerular nephropathy by 8
weeks and histological
characteristics of advanced
diabetic nephropathy by 20 - 22
weeks.
Peripheral neuropathy
Myocardial disease
Impaired wound healing
Infertility in F hom ;
Subfertility in M hom
Hypothermic
