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Speed Congenics

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CONTACT JAX 1.800.422.6423 (US) (International) LEARN MORE ABOUT JAX MICE AND SERVICES JAX.ORG/JMCRS Speed Congenics Using Speed Congenics, we can take your strain and produce genetically well-defined congenic mice of high health status in half the time of traditional backcrossing. Transfers a mutation from one background to another using marker (SNP)-assisted backcrossing. Goal to obtain >99% genetic contribution of new strain background. Overview ∙ Reduced time to generate congenic strain from >3 years to ~18 months. ∙ Delivers genetically well-defined, SOPF mice. ∙ All biosampling, analysis, and breeding is handled by JAX. ∙ We manage the project and deliver high health status confirmed congenic mice breeding pair back to you. Features and Benefits ∙ Move a mutation into a background on a drastically reduced timeframe. ∙ Breed out unwanted genetic contributions from mixed backgrounds. ∙ Quickly move to the genetic background of your choice when starting with traditional transgenic models, which are often generated in 129 or other ES cells. This strategy may offer a comparable timeline when CRISPR methods are not feasible in the preferred background. Applications Considerations ∙ Timeline and price of breeding projects may vary based on the breeding characteristics of the strains. ∙ JAX Model Generation Services may be able to recreate the desired allele in the background of your choice faster and more cost-effectively. ∙ For non-JAX strains, this service will require Rederivation prior to breeding. External strains will also require you to provide primer sequences for genotyping. Related Services ∙ Custom Breeding or Speed Expansion can be added to provide study ready cohorts of the new background mice. ∙ Sperm and/or Embryo Cryopreservation of mice on the new background. TS0039 2022.09

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