Research paper

Comparison of outcomes across low-intensity psychological interventions for depression and anxiety within a stepped-care setting A naturalistic cohort study using propensity score modelling

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1 SilverCloud Research, SilverCloud Health, Dublin, Ireland 2 E-mental Health Research Group, School of Psychology, Trinity College Dublin, Dublin, Ireland 3 Berkshire Healthcare NHS Foundation Trust, Bracknell, UK Correspondence Jorge Palacios, School of Psychology, Aras an Phiarsaigh, Trinity College Dublin, Dublin, Ireland. Email: jorge.palacios@tcd.ie Funding information SilverCloud Health; Berkshire Healthcare Foundation Trust Abstract Low-intensity interventions for common mental disorders (CMD) address issues such as clinician shortages and barriers to accessing care. However, there is a lack of research into their comparative effectiveness in routine care. We aimed to compare treatment effects of three such interventions, utiliz- ing four years' worth of routine clinical data. Users complet- ing a course of guided self-help bibliotherapy (GSH), internet-delivered cognitive behavioural therapy (iCBT) or psychoeducational group therapy (PGT) from a stepped-care service within the NHS in England were included. Propen- sity score models (stratification and weighting) were used to control for allocation bias and determine average treat- ment effect (ATE) between the interventions. 21,215 users comprised the study sample (GSH = 12,896, iCBT = 6862, PGT = 1457). Adherence-to-treatment rates were higher in iCBT. All interventions showed significant improvements in depression (PHQ-9), anxiety (GAD-7) and function- ing (WSAS) scores, with largest effect sizes for iCBT. Both propensity score models showed a significant ATE in favour of iCBT versus GSH and PGT, and in favour of GSH versus PGT. Discernible differences in effectiveness were seen for iCBT in comparison with GSH and PGT. Given vari- ance in delivery mode and human resources between differ- ent low-intensity interventions, building on these findings A R T I C L E Comparison of outcomes across low-intensity psychological interventions for depression and anxiety within a stepped-care setting: A naturalistic cohort study using propensity score modelling Jorge Palacios 1,2 | Adedeji Adegoke 1 | Rebecca Wogan 1 | Daniel Duffy 1,2 | Caroline Earley 1,2 | Nora Eilert 1,2 | Angel Enrique 1,2 | Sarah Sollesse 3 | Judith Chapman 3 | Derek Richards 1,2 DOI: 10.1111/bjop.12614 Received: 18 June 2021 Accepted: 12 November 2022 This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2022 The Authors. British Journal of Psychology published by John Wiley & Sons Ltd on behalf of The British Psychological Society. Br J Psychol. 2023;114:299–314. wileyonlinelibrary.com/journal/bjop 299

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