CONTACT JAX
micetech@jax.org
TS0251 2024.08
1.800.422.6423 (US)
1.207.288.5845 (International)
Humanization of Antibody Variable Domains in Mice
Atlas™ Mice are a unique platform with the improved speed, diversity, developability, and affinity
that are core to knock-in transgenic antibody mice. Partnering with AbTherx, The Jackson
Laboratory is committed to offering this innovative platform with increased accessibility for drug
developers of all sizes.
Atlas™ Mice
(Developed by AbTherx)
Overview
Atlas™ Mice were created through the intentional knock-in of human antibody regions into the mouse
endogenous immunoglobulin loci, with discrete models to enable the generation of both monoclonal and
bispecific antibodies. By containing the near full complement of human antibody gene sequence diversity,
Atlas
TM
Mouse antibodies are selected for and matured in vivo, simplifying downstream engineering and
streamlining the discovery and development process.
Atlas™ Full Human Diversity Mouse for
Monoclonal Antibody Discovery
∙ Full-diversity human heavy chain and kappa light chain
∙ Variable regions comprising >99% of commonly
expressed human sequences
∙ Use of only functional variable heavy and kappa light
chain regions, without pseudogenes or duplicates
Atlas™ Binary Fixed Light Chain Mouse
for Bispecific and Multispecific Antibody
Discovery
∙ Common light chain enables the creation of bispecific
antibodies with a structure that is most similar to a
native antibody
∙ Stochastic choice from one of two fixed light chains with
overlapping but distinct abilities to pair with diverse
heavy chains
∙ Variable regions comprising >99% of commonly
expressed human heavy chain sequences
LEARN MORE
AT JAX.ORG
