Partnering with AbTherx, The Jackson Laboratory is committed to offering this innovative
platform with increased accessibility for drug developers of all sizes.
Empowering Creators & Innovators with
Next-Generation Antibody Discovery Technologies
Overview
Transgenic mice are the gold standard for therapeutic antibody discovery,
enabling superior speed, diversity, developability and affinities. Over two thirds of
FDA-approved human antibodies are derived from transgenic mice
1
and antibodies
from transgenic mice are six times more likely to have desirable biophysical
properties when compared to in vitro display.
2
Atlas™ Mice are a transgenic platform for antibody discovery created through
the intentional knock-in of human antibody regions into the mouse endogenous
immunoglobulin loci, with discrete models to enable the generation of both
monoclonal and bispecific antibodies. By containing the near full complement of
human antibody gene sequence diversity, Atlas™ Mouse antibodies are selected
for and matured in vivo, simplifying downstream engineering and streamlining the
discovery and development process.
Atlas™ Mice
TS0251 2025.02
