Issue link: https://read.uberflip.com/i/1545146
The Jackson Laboratory (JAX) provides a comprehensive human induced pluripotent stem cell (iPSC) catalog supporting disease modeling and discovery at scale. With more than 700 genetically engineered isogenic lines generated from well-characterized healthy iPSC backgrounds, alongside donor-derived iPSC lines that capture human genetic diversity and disease heterogeneity, researchers can select fit-for-purpose models that deliver robust, reproducible biological insight. JAX iPSCs undergo rigorous quality control and characterization to ensure consistent performance in disease modeling and discovery research. Leveraging the automated JAX- NYSCF Global Stem Cell Array ® , JAX standardizes manufacturing and quality control across lines, minimizing batch-to-batch and vial-to-vial variability which supports reproducibility across experiments. Together, our iPSC catalog supports integrated and iterative research workflows - from target discovery and isogenic validation to modeling patient and disease diversity - allowing researchers to move more quickly and confidently from hypothesis to insight. Genetically Engineered Isogenic iPSC Lines Donor-Derived Disease-Specific iPSC Lines Overview Isogenic lines engineered on a uniform genetic background with disease-relevant mutations, gene knockouts, and other gene edits, enabling precise and comparable phenotypic analysis Donor-derived lines generated from diverse individuals that retain disease- associated genetic variants, enabling modeling of disease complexity and biological heterogeneity Source Rigorously characterized, genetically stable iPSC reference lines, including KOLF2.1J Fibroblasts or PBMCs obtained from donors across multiple disease cohorts and healthy controls Major Disease Areas • Alzheimer's & Related Dementias • Parkinson's Disease, ALS • Neurodevelopmental disorders • Neurodegenerative disorders • Rare genetic disorders • Cancer Popular Lines • Single-nucleotide variant lines with matched revertants to isolate variant- specific effects • HaloTag ® lines for real-time insights into protein dynamics • Tet-inducible transcription factor lines for controlled differentiation • Diverse collection of control iPSC lines enabling matching by sex, age, and race/ ethnicity • Cohort of Parkinson's disease iPSC lines, supporting studies of disease heterogeneity Powering Discovery with JAX iPSC Models