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The JAX-NYSCF Global Stem Cell Array® Automated stem cell reprogramming, genome editing, and differentiation. Our A reas of Focus • Provide the scientific communit y with high- qualit y iPSC lines • Accelerate precision medicine research and drug discover y in patient-specific, disease -relevant cell t ypes • Facilitate func tional genetics studies of disease -associated variants and pathways through genome editing The JA X- N YSCF Global Stem Cell Array ® • Fully automated, highly reproducible production of iPSC lines • Stringent quality control • Industrial-scale produc tion • Advanced line tracking and data management systems • Read Paull , D. et al . Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nat . Methods 12, 885–892 (2015) Best-in-class Automation Technolog y • Eliminates all manual manipulation • Massively parallel processing of samples • Significantly reduces line-to-line variability • Yields highly reproducible sets of iPSCs and dif ferentiated lines Pancreatic organoids Astrocytes GFAP S100B DAPI ZO-1 Hoechst Phalloidin NKX6.1 Insulin Immunostained iPSCs generated by the NYSCF Global Stem Cell Array ® Neurons Cortical organoids Actin NANOG TRA-1-60 Quality Stem Cell Derivation, Differentiation, and Genome Editing • Fully automated reprogramming of skin and blood samples into iPSCs • Cer tificate of Analysis provided for each line with comprehensive qualit y control • Automated CRISPR/Cas9 knockouts • Precision genome editing for produc tion of isogenic control lines • High-yield protocol s for dif ferentiating iPSCs into all major brain cell t ypes including neurons and glia; hepatocy tes, pancreatic beta cell s/ organoids, cardiomyocy tes, retinal pigmented epithelia, immune cell s, neural progenitors/ organoids • Marker-based isolation of pure dif ferentiated populations HOECHST eGFP GABA TUJ1 CTIP2 SOX2 TBR1 HOECHST Retinal Pigmented Epithelia OP0288